The River Corridor includes the former fuel fabrication facilities at Hanford’s 300 Area, just north of the city of Richland, and nine former plutonium production reactors along the Columbia River. The reactor areas are also known as the 100 Areas. In addition, considerable land area not directly involved in plutonium production, must be cleaned up, preserved or protected in some way. The 220-square-mile River Corridor region sits adjacent to a 50-plus-mile stretch of the Columbia River.

The cleanup of the River Corridor mainly involves the decommissioning, decontamination and demolition of contaminated facilities, clean up and removal of contaminated soil and debris from waste sites, and groundwater treatment. Workers have been cleaning up the hazards that most directly threaten the nearby Columbia River, with tremendous progress being made since 2005.

Links to facilities and burial grounds that are part of Hanford's River Corridor:

• 100 K Area
• 200 Area
• 300 Area
• 324 Building
• 325 Building
• 618-10 Burial Ground
• 618-11 Burial Ground
• B Reactor
• C Reactor
• D and DR Reactors
• F Reactor
• H Reactor
• K West Basin Sludge Treatment Project
• N Reactor